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(617) 525-5863

Center Director

Professor of Medicine

Harvard Medical School and Brigham and Women's Hospital

Jing Zhou, MD, PhD is the founding director of the Harvard Center for Polycystic Kidney Disease Research which was established via funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in 2005. Dr. Zhou’s research focuses on the understanding of inherited kidney disease. Dr. Zhou is an internationally renowned leader on studies of polycystic kidney disease. In the past 20 years of studies of polycystic kidney disease, Dr. Zhou has made outstanding contributions in many areas of PKD research including the creation of the first targeted mouse model for polycystic kidney disease, the identification of ion channel function of polycystin protein family to the understanding  of polycystin biology.

Dr. Jing Zhou graduated from Shanghai Medical University in China and Oulu University in Finland. She joined the Harvard faculty as Assistant Professor in 1993, after her postdoctoral training at Yale and six year of medical practice in China. Dr. Zhou is Professor of Medicine at the Harvard Medical School and a member of the renal division at the Brigham and Women’s Hospital and the Genetics Department at Harvard Medical School. Dr. Zhou is the first female recipient of the Young Investigator Award from the American Society of Nephrology and American Heart Association (2001) and the first women recipient of the Lillian Jean Kaplan International Prize jointly awarded by the International Society of Nephrology, Lillian Jean Kaplan Foundation and the Polycystic Kidney Disease Foundation (2007). Dr. Zhou has served on a variety of national and international grants review committees including a 4-year term as a permanent member of General Medicine B and Cellular and Molecular Biology of the Kidney at NIH and a 7-year term as a member of the Scientific Advisory Board of Polycystic Kidney Disease Foundation. Dr. Zhou has delivered over 100 scientific lectures and chaired over 20 sessions at National or International meetings. In her leisure time, Dr. Zhou enjoys cooking, reading, and gardening.


For more publications click here.

Original Articles:

Peissel, B, Geng L, Kalluri R, Kashtan K, Rennke HG, Gallo GR, Sun MJ, Hudson BG, Neilson EG and Zhou J. Comparative distribution of the a1(IV), a5(IV) and a6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients. J Clin Invest 1995; 96:1948-1957.

International PKD Consortium. Polycystic kidney disease: The complete structure of the PKD1 gene and its protein. Cell 1995; 81:289-298.

Schneider MC, Rodriguez A, Nomura N, Zhou J, Morton, C, Reeders ST and Stanislawa W. Mapping of polycystwin, a gene homologous to the carboxyl terminus of PKD1, to chromosome 4q22: a candidate locus for PKD2. Genomics 1996; 38:1-4.

Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke HG, Glucksmann-Kuis S, Schneider MC, Ericsson M, Reeders ST and Zhou J. Identification and Localization of Polycystin, the PKD1 Gene Product. J Clin Invest 1996; 98:2674-2682.

Lu WN, Peissel B, Babakhanlou H, Fan XH, Pavlova A, Geng L, Larson C, Brent G, and Zhou J. Perinatal lethality and defects with kidneys and pancreas defects in mice with targeted Pkd1 Nature Genetics 1997; 17:179-181.

Geng L, Segal Y, Pavlova A, Barros EJG.; Löhning C, Lu W, Nigam S.K, Frischauf AM, Reeders ST and Zhou J. Distribution and developmentally regulated expression of murine polycystin. Am J Physiol 1997; F451-F459.

Nomura H, Turco AE, Pei Y, Kalaydjieva L, Weremowicz S, Ji W, Morton C, Meisler M, Reeders, ST, and Zhou J. Identification of PKDL, a novel polycystic kidney disease 2-like gene, whose murine homologue is deleted in mice with kidney and retinal defects. Biol. Chem 1998; 273(40):25967-25973.

Segal Y, Peissel B, Renieri A, de Marchi M, Ballabio A, Pei Y, and Zhou J. Line-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis, Am J Hum Genet 1999; 64(1):62-9.

Lu WN, Fan XH, Basora N, Babakhanlou H, Law T, Rifai N, Harris PC, Perez-Atayde AR, Rennke HG and Zhou J. Late onset of renal and hepatic cysts in mice heterozygous for a targeted Pkd1 Nature Genetics 1999; 21(2):160-161.

Chen, XZ, Vassilev, PM, Basora, N, Peng, JP, Nomura, N, Segal, Y, Brown, EB, Reeders, ST, Hediger, MA, and Zhou, J. Polycystin-L, a member of the polycystin family of proteins, is a calcium-permeable cation channel. Nature 1999; 401:383-386.

Guo, L, Chen, MH, Basora, N, and Zhou, J. The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. Mammalian Genome 2000; 11(1):46-50.

Guo L, Schreiber TH, Weremowicz S, Morton CC, and Zhou J. Molecular cloning and characterization of a novel polycystin family member, polycystin-l2, in mouse and man. Genomics 2000; 64:241-251.

Segal Y, Rondeau E and Zhou J. Identification of cis-acting elements and promoter configuration of the type IV collagen gene COL4A5 and COL4A6. Biol. Chem 2001; 276(15):11791-7.

Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev P, Brown EM, Hediger MA, and Zhou J. The transport function of the naturally occurring pathogenic polycystin‑2 mutant, R742X. Biochem Biophys Res Commun 2001; 282(5):1251-6.

Vassilev P, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M, Ye CP, Brown EM, Hediger MA, and Zhou J. Polycystic kidney disease 2 gene encodes a novel high conductance channel implicated in defective intracellular Ca2+ Biochem Biophys Res Commun 2001; 282(1):341-350.

Lu WN, Shen X, Pavlova A, Lakkis M, Ward C, Pritchard L, Harris P, Genest D, Perez-Atayde A, and Zhou J. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genetics 2001; 10(21):2385-2396.

Basora N, Nomura H, Berger U, Stayner C, Guo L, Shen XH, and Zhou J. Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. J Am Soc Nephrol 2002; 13(2):293-301.

Delmas P, Nomura H, Li X, Lakkis M, Luo Y, Segal Y, Fernández-Fernández J, Harris P, Frischauf AM, Brown DA and Zhou J. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. Biol. Chem 2002; 277(13):11276-83.

Yuasa T, Venugopal B, Weremowicz S, Morton CC, Guo L, and Zhou J. A Novel Polycystic Kidney Disease 1 Like Gene, PKD1L1, in Human: Sequence, Expression, and Chromosomal Localization. Genomics 2002; 79(3):376-86.

Sun Y, Zhou J, Stayner C, Fielding J, Shen X, Munasinghe J, Beier BR and Albert MRI assessment of a murine model of recessive polycystic kidney disease. Comparative Medicine 2002; 52:433- 438.

Liu Y, Li Q, Tan M, Zhang Y, Karpinski E, Zhou J, Chen X. Modulation of the human polycystin-L channel by voltage and divalent cations. FEBS Lett. 2002; 525(1-3):71.

Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AEH, Lu W, Brown EM, Quinn SJ, Ingber DE, and Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genetics (Article) 2003; 33(2):129-37.

Luo Y, Vassilev P, Li X, Kanawabe Y, and Zhou J. Native polycystin-2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol 2003; 23(7):2600-7.

Loghman-Adham M, Nauli S, Soto CE, Kariuki B, and Zhou J. Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts. Am J Physiol 2003; 285(3):F397-412.

Herzog C, Zhuang LY, Gorgan, L, Segal Y, and Zhou J. Identification of cis-regulatory elements that contribute to tissue- and site-specific a5(IV) and a6(IV) collagen expression in vivo. Biochem Biophys Res Commun 2003; 311(2):553-60.

Wang S, Luo Y, Wilson PD, Witman G, Zhou J. Autosomal recessive polycystic kidney disease protein is concentrated in the basal body area of primary cilia. J Am Soc Nephrol 2004; 15(3):592-602.

Delmas P, Nauli SM, Li X, Lakkis M, Luo Y, Elia A, Williams E, Frischauf AM, Crest M, Brown DA and Zhou J. Gating of the polycystin channel complex by conformational change of polycystin-1. FASEB 2004; 18(6):740-2.

Yuasa T, Takakura A, Denker BM, Venugopal B, and Zhou J. Polycystin-1L2 is a novel G-protein binding protein. Genomics 2004; 84(1):126-38.

Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber D. Global cytoskeletal control of mechanotransduction in kidney epithelial cells, Exp Cell Res 2004; 301(1):23-30.

Sharma M, Brantley JG, Alcalay NI, Zhou J, Heystek E, Maser RL, and Vanden Heuvel GB. Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice. Kidney Int 2005; 67(2):432-42.

Hughes P, Robati M, Lu W, Zhou J, Strasser A, Bouillet P. Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ, 2005 Nov 11. [Epub ahead of print]

Li XG, Luo Y, Starremans P, McNamara CA, Pei Y, and Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle and cell differentiation. Nat Cell Biol 2005;7(12):1102-12. Epub 2005 Nov 27.

Oslen BR, Kolpacova E, McBratney-Owen B, Zhou J, Fukai N. Genetic and Epigenetic Determinants of skeletal morphogenesis-role of cellular polarity and ciliary function in skeletal development and growth. Oral Biosci Med, 2005;2/3:57-65.

Nauli SM, Rossetti S, Kolb RJ, Alenghat AJ, Harris PC, Ingber DE, Loghman-Adham M, Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol, 2006, Apr;17(4):1015-25

Bui-Xuan EF, Li Q, Chen XZ, Boucher CA, Sandford R, Zhou J, Basora N. More than colocalizing with polycystin-1, polycystin-L is in the centrosome. Am J Physiol Renal Physiol. 2006 Aug;291(2):F395-406. Epub 2006 Apr 11.

Wilson SJ, Amsler K, Hyink DP, Li X, Lu W, Zhou J, Burrow CR, Wilson PD. Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia. Biochim Biophys Acta. 2006 Jul;1762(7):647-55. Epub 2006 May 19.

Stayner C, Iglesias DM, Goodyer PR, Ellis L, Germino GG, Zhou J, Eccles MR. Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Hum Mol Genet. 2006 Dec 15;15(24):3520-8. Epub 2006 Nov 2.

Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, Gerszten RE, Zhou J, Ingber DE, Kalluri R, Pollak MR. a-actinin-4 is required for normal podocyte adhesion. J Biol Chem. 2007 Jan 5;282(1):467-77. Epub 2006 Nov 2.

Wang SX, Zhang JJ, Nauli SM, Li X, Starremans P, Luo Y, Roberts KA, Zhou J. Fibrocystin is associated with polycystin-2 and regulates intracellular calcium concentration. Mol Cell Biol. 2007 Apr;27(8):3241-52. Epub 2007 Feb 5.

Tian Y, Kolb R, Hong JH, Carroll J, Li DW , You You, Bronson Y, Yaffe YB, Zhou J, Benjamin T. TAZ Functions in a SCFb-Trcp E3 Ligase Pathway: Implications for Polycystic Kidney Disease. Mol Cell Biol. 2007 Jul 16; [Epub ahead of print].

Sohara E, Luo Y, Zhang JJ, Qiu H, Beier DR and Zhou J. Nek8 kinase regulates the ciliary expressions and localizations of polycystin-1 and polycystin-2. J Am Soc Nephrol, 2008, Jan 30. [E-pub ahead of print].

Nauli SM, Kawanabe Y, Haycraft CJ, Kaminski JJ, Ingber DE, Yoder B and Zhou J. Endothelial cilia regulate calcium signaling and nitric oxide production through polycystin-1. Circulation, 2008 Feb 19: [E-pub ahead of print].

Dedoussis GV, Luo Y, Starremans P, Rossetti S, Ramos AJ, Cantiello HF, Katsareli E, Ziroyannis P, Lamnissou K, Harris PC, Zhou J. Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease. Eur J Clin Invest. 2008 Mar;38(3):180-90.

Starremans P, Li XG, Finnerty PE, Guo L, Neilson EG, Zhou J. A mouse model for polycystic kidney disease by a somatic in-frame deletion in the 5’ end of Kidney Int. 2008 Apr 2; [Epub ahead of print].

Kolpakova-Hart E, Nicolae C, Zhou J and Olsen BR Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes, Matrix Biology, Jul;27(6):505-12. Epub 2008 May 27

Kolpakova-Hart E, McBratney-Owen B, Hou B, Fukai N, Nicolae C, Zhou J, Olsen BR. Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol, 2008, Sep 15;321(2):407-19. Epub 2008 Jul 9.

Takakura A, Contrino L, Beck A and Zhou J. Focal cystic disease in mice with Pkd1 inactivation induced in adulthood. J Am Soc Nephrol, 2008, Sep 5. [Epub ahead of print]

Alcalay NI, Sharma M, Vassmer D, Chapman B, Paul B, Zhou J, Brantley JG, Wallace DP, Maser RL, Vanden Heuvel GB. Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1. Am J Physiol Renal Physiol. 2008 Oct 1. [Epub ahead of print]

Zhang P, Luo Y, Gonzalez-Perrett S, Montalbetti N, Timpanaro G, Cantero M, Ramos A, Goldmann W, Zhou J, Cantiello H. The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and heteromultimers with TRPC1. Hum Mol Genet, 2009, Apr 1;18(7):1238-51. Epub 2009 Feb 3

Takakura A, Contrino L, Zhou X, Bonventre JV, Sun Y, Humphreys BD and Zhou J. Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet, 2009 Jul 15;18(14):2523-31. doi: 10.1093/hmg/ddp147. Epub 2009 Apr 2.

Kong T, Xu D, Yu W, Takakura A, Boucher I, Tran M, Kreidberg JA, Shah J, Zhou J, Denker BM. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-i and blocks tubulogenesis. Mol Biol Cell, 2009 vol. 20 (21) pp. 4596-610

Zhou X, Bao H, Takakura A, Zhou J, Albert M, Sun Y. Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP. Invest Radiol, 2010 vol. 45 (1) pp. 24-8

Besschetnova TY, Kolpakova-Hart E, Guan Y, Zhou J, Olsen BR, Shah JV. Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Current Biology. 2010 Jan 26;20(2):182-7. Epub 2010 Jan 21.

Subramanian B, Rudym D, Cannizzaro C, Peronne R, Zhou J, Kaplan DL. Tissue Engineered 3D in vitro Models for Normal and Diseased Kidney. Tissue Eng Part A. 2010 Sep;16(9):2821-31.

Luyten A, Su X, Gondela S, Chen Y, Takakura A, Zhou J. Aberrant regulation of planar cell polarity pathway in human and mouse polycystic kidney disease. J Am Soc Nephrol Sep;21(9):1521-32. Epub 2010 Aug 12.

Zhang J, Wu M, Wang S, Shah J, Wilson PD, Zhou, J. Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity. Hum Mol Genet, Sep 1;19(17):3306-19. Epub 2010 Jun 16.

Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM. Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis. Cell Signal. 2011 Jan;23(1):213-21. Epub 2010 Sep 17.

Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest. 2010 Oct 1;120(10):3617-28. doi: 10.1172/JCI41531. Epub 2010 Sep 13.

Pandey P, Qin S, Ho J, Zhou J, Kreidberg JA. Systems biology approach to identify transcriptome reprogramming and microRNA targets during the progression of Polycystic Kidney Disease. BMC Syst Biol. 2011 Apr 25;5(1):56. [Epub ahead of print]

Shen C, Beroukhim R, Schumacher S, Zhou, J., Chang, M., Signoretti, S., & Kaelin, W. Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene. Cancer Discovery 2011. Published Online First on June 16, 2011.

Takakura A, Nelson EA, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet. Published Online on Aug 22, 2011 20(21):4143-4154.

Qin S, Taglienti M, Cai L, Zhou J, Kreidberg JA. c-Met and NF-κB-Dependent Overexpression of Wnt7a and -7b and Pax2 Promotes Cystogenesis in Polycystic Kidney Disease. J Am Soc Nephrol 23, 1309-1318. 2012 Jun 7. [Epub ahead of print].

Subramanian, B., Ko, W.C., Yadav, V., Desrochers, T.M., Perrone, R.D., Zhou, J., and Kaplan, D.L. (2012). The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions. Biomaterials. 2012, 1-13.

Yao G, Luyten A, Takakura A, Plomann M, and Zhou J. The cytoplasmic protein Pacsin 2 in kidney development and injury repair. Kidney Int. 2013 Mar;83(3):426-37. doi: 10.1038/ki.2012.379. 2012 Dec 12. [Epub ahead of print].

Zeng, L., Bai, M., Mittal, A.K., El-Jouni, W., Zhou, J., Cohen, D.M., Zhou, M.I., and Cohen, H.T. (2013). Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. Cancer Res 73, 5371-5380.

Freedman BS, Lam AQ, Sundsbak JL, Latrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonvetre BV. Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 J Am Soc Nephrol, 2013 Oct;24(10):1571-86.

Aboualaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2013 Nov 14, 2013 [Epub ahead of print]

Yao G, Su X, Nguyen V, Roberts K, Li X, Takakura A, Plomann M, and Zhou J. Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. Hum Mol Genet Hum Mol Genet. 2014 May 15;23(10):2769-79. doi: 10.1093/hmg/ddt672. Epub 2014 Jan 2.

Inoue1 Y, Sohara E, Chiga M, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sei Sasaki S, Uchida S. Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in AQP11 knockout mice. J Am Soc Nephrol, 2014 May 22. pii: ASN.2013060614. [Epub ahead of print].

Wang S, Wu M, Yao G, Zhang J, and Zhou J. The cytoplasmic tail of FPC antagonizes the full-length protein in the regulation of mTOR pathway. PLoS One. 2014 May 22;9(5):e95630. doi: 10.1371/journal.pone.0095630. eCollection 2014..

Su X, Driscoll K, Yao G, Raed A, Wu M, Beales PL, Zhou J. Bardet Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein, Hum Mol Genet. 2014 Oct 15;23(20):5441-51. doi: 10.1093/hmg/ddu267. Epub 2014 Jun 16.

Jin X, Muntean BS, Aal-Aaboda M, Duan Q, Zhou, J. Nauli S. L-type Calcium Channel Modulates Polycystic Kidney Phenotype. BBA – Molecular Basis of Disease. Biochim Biophys Acta. 2014 Jun 9;1842(9):1518-1526. doi: 10.1016/j.bbadis.2014.06.001. [Epub ahead of print].

DesRochersa TM, Palmaa E, Jandhyalabc DM, El-Jouni W, Zhou J, Thorpec C, Leongb JM, and Kaplan DL. The effects of shiga toxin on a bioengineered 3d model of human renal tissue. Infection and Immunity. 2014.

Reviews, Chapters and Editorials:

Tryggvason K, Zhou J, Hostikka SL, Sariola H. Collagene de type IV dans la membrane basale glomulerulaire normale et anormale. In: Actualities nephrologiques Jean Hamburger. Funck-Brentano JL, Bach JF, Kreis H, Grunfeld JP, eds. Flammarion, Paris, Hospital Necker, Medecine-Sciences, 1992: 1-13.

Tryggvason, K., Zhou, J., Hostikka, S.L. and Sariola, H.: Type IV collagen in normal and diseased glomerular basement membrane. In: Advances in Nephrology (Grünfeld, J.-P., Bach, J.F., Kreis, H. and Maxvell, M.H. eds.) Necker Hospital, Mosby-Year Book 22, 1-14, 1993.

Tryggvason K, Zhou J, Hostikka SL. Alport syndrome and other inherited basement membrane disorders. In: Timpl R, Rohrbach DH, eds. Molecular and Cellular Aspects of Basement Membranes. Saint Louis Missouri, Academic Press Inc. 1993: 421-35.

Zhou J and Reeders S.T. The a chains of type IV collagen. In: Alport Syndrome. Tryggvason K, eds. Contrib. Nephrol. Basel, Karger, 1996. 117:80-104.

Reeders S.T. and Zhou J. Molecular genetics of renal disorders. In: Oxford Textbook of Clinical Nephrology. Cameron S, Davison AM, Grünfeld JP, Kerr D, Ritz E, eds. Oxford, Oxford University Press, 1998:2375-2384.

Stayner C., Zhou J: Polycystin channels and kidney disease. Invited review, Trends in Pharmacological Sciences, 2001, 22 (11) 543-546.v

Lakkis M., Zhou J. Molecular complexes formed with polycystins. Nephron. Invited review, 2003; 93(1):E3-8.

Nauli S.M., Zhou J. Polycystins and mechanosensation in renal and nodal cilia. Bioassays, Invited Review, 2004; 26(8):844-56.

Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr. 2006 Aug;149(2):159-64.

Zhou J and Pei Y, Autosomal dominant polycystic kidney disease. In: Mount and Pollak, The Molecular and Genetic Basis of Kidney Disease. A Companion to Brenner and Rector’s The Kidney. Elsevier, 2007 Oct:85-171

Zhou J, Polycystins and primary cilia, primers for cell cycle progression. Ann Rev Physiol, 2009, 71:83-113.

Nauli S.N., Jin X., AbouAlaiwi W.A., El-Jouni W., Su X., and Zhou J. Non-motile primary cilia as fluid shear stress mechanosensors, Elsevier’s Methods in Enzymology. 2013;525:1-20.

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