Professor of Pediatrics and Surgery
Harvard Medical School and Boston Children's Hospital
A major goal of our present research is to understand the mechanism of cyst formation in polycystic kidney disease. My laboratory takes a developmental approach to organ-based disease, examining how aberrant regulation of developmental pathways results in organ-based disease. A major area of interest is in the role of integrins in kidney development and disease. We have found that coordinate signal transduction between a3b1 integrin and the receptor tyrosine kinase c-Met regulates Wnt gene expression during development. We are presently investigating mis-regulation of this pathway in PKD.
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Pandey, P., Qin, S., Ho, J. Zhou, J. and Kreidberg, J.A. Systems biology approach to identify transcriptional reprogramming and microRNA targets during progression of Polycystic Kidney Disease. (In Press, BMC System Biology 2011 Apr 25;5:56. PMID: 21518438
Qin, S., Taglienti, M., Nauli, S.M., Contrino, L.,Takakura, A., Zhou, J. and Kreidberg, J.A. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease J. Clinical Investigation 2010 120(10):3617-3628
Hartwig, S., Ho, J., Pandey, P., MacIsaac, K., Taglienti, M., Xiang, M., Alterovitz, G., Ramoni, M., Fraenkel. E., and Kreidberg, J.A. . Genomic Characterization of Wilms’ Tumor Suppressor-1 Targets in Nephron Progenitor Cells during Kidney Development. Development. 2010 137:1189-1203