Clinical Professor of Medicine
Harvard Medical School and Beth Israel Deaconess Medical Center
Dr. Theodore Steinman has been involved in PKD clinical research since the early 1980s, starting with the MDRD study. For the last decade the major clinical projects have been the:
1. HALT PKD Study – an 8 year study of 1054 patients with ADPKD (both Type 1 and Type 2). This is the longest and largest study ever donme in the PKD population.
2. Otsuka Observational Study – a 2 year study examining the natural course history of ADPKD. This observation study will serve as a baseline for any interventional studies that may/will follow in the future.
3. Kadmon Study – a multi-targeted tyrosine kinase inhibitor that is designed to slow/stop cyst growth in the PKD population.
Pain management in PKD has been of major interest to Dr. Steinman for the past 25 years and the clinical investigation of over 300 PKD patients with pain issues has led to a series of articles that that defined the etiology of pain in this population, various approaches to pain control, and when to use laparoscopic cyst decortication.
The most recent work has been part of a team investigating in the PKD population the aspect of induced pluripotent stem cells from this group, with both PKD type 1 and 2, to differentiate into intermediate mesoderm that form tubules that express kidney proximal tubule markers.
For more publications click here.
Riella C, Czarnecki PG, Steinman TI. Therapeutic advances in the treatment of polycystic kidney disease. Nephron Clin Pract. 2014;128(3-4):297-302. doi: 10.1159/000368244. Epub 2015 Jan 6. PMID: 25573484
Schrier RW, Abebe KZ, Perrone RD, Torres VE, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czarnecki PG, Hogan MC, Miskulin DC, Rahbari-Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Bae KT, Moore CG, Chapman AB; HALT-PKD Trial Investigators. Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med. 2014 Dec 11;371(24):2255-66. doi: 10.1056/NEJMoa1402685. Epub 2014 Nov 15.
Torres VE, Abebe KZ, Chapman AB, Schrier RW, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czarnecki PG, Hogan MC, Miskulin DC, Rahbari-Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Moore CG, Perrone RD; HALT-PKD Trial Investigators. Angiotensin blockade in late autosomal dominant polycystic kidney disease. N Engl J Med. 2014 Dec 11;371(24):2267-76. doi: 10.1056/NEJMoa1402686. Epub 2014 Nov 15. PMID: 25399731
Garg N, Steinman TI. Role of sodium restriction in recurrent stone formers with hyperoxaluria. Am J Kidney Dis. 2014 Sep;64(3):478. doi: 10.1053/j.ajkd.2014.03.023. No abstract available. PMID: 25150857
Hogan MC, Abebe K, Torres VE, Chapman AB, Bae KT, Tao C, Sun H, Perrone RD, Steinman TI, Braun W, Winklhofer FT, Miskulin DC, Rahbari-Oskoui F, Brosnahan G, Masoumi A, Karpov IO, Spillane S, Flessner M, Moore CG, Schrier RW. Liver involvement in early autosomal-dominant polycystic kidney disease. Clin Gastroenterol Hepatol. 2015 Jan;13(1):155-64.e6. doi: 10.1016/j.cgh.2014.07.051. Epub 2014 Aug 9. PMID: 25111236
Miskulin DC, Abebe KZ, Chapman AB, Perrone RD, Steinman TI, Torres VE, Bae KT, Braun W, Winklhofer FT, Hogan MC, Rahbari-Oskoui F, Moore CG, Flessner MF, Schrier RW; HALT-PKD Study. Health-related quality of life in patients with autosomal dominant polycystic kidney disease and CKD stages 1-4: a cross-sectional study. Am J Kidney Dis. 2014 Feb;63(2):214-26. doi: 10.1053/j.ajkd.2013.08.017. Epub 2013 Nov 1. PMID: 24183837
Steinman TI. The older patient with end-stage renal disease: is chronic dialysis the best option? Semin Dial. 2012 Nov-Dec;25(6):602-5. doi: 10.1111/sdi.12035. PMID: 23173889
Parker TF 3rd, Straube BM, Nissenson A, Hakim RM, Steinman TI, Glassock RJ. Dialysis at a crossroads–Part II: A call for action.
Clin J Am Soc Nephrol. 2012 Jun;7(6):1026-32. doi: 10.2215/CJN.11381111. Epub 2012 Apr 12. PMID: 22498499
Steinman TI. Polycystic kidney disease: a 2011 update. Curr Opin Nephrol Hypertens. 2012 Mar;21(2):189-94. doi: 10.1097/MNH.0b013e32835011a7. Review. PMID: 22274800 [PubMed – indexed for MEDLINE]