Clinical Professor of Medicine
Senior Physician
Harvard Medical School and Beth Israel Deaconess Medical Center
Dr. Theodore Steinman has been involved in PKD clinical research since the early 1980s, starting with the MDRD study. For the last decade the major clinical projects have been the:
1. HALT PKD Study – an 8 year study of 1054 patients with ADPKD (both Type 1 and Type 2). This is the longest and largest study ever donme in the PKD population.
2. Otsuka Observational Study – a 2 year study examining the natural course history of ADPKD. This observation study will serve as a baseline for any interventional studies that may/will follow in the future.
3. Kadmon Study – a multi-targeted tyrosine kinase inhibitor that is designed to slow/stop cyst growth in the PKD population.
Pain management in PKD has been of major interest to Dr. Steinman for the past 25 years and the clinical investigation of over 300 PKD patients with pain issues has led to a series of articles that that defined the etiology of pain in this population, various approaches to pain control, and when to use laparoscopic cyst decortication.
The most recent work has been part of a team investigating in the PKD population the aspect of induced pluripotent stem cells from this group, with both PKD type 1 and 2, to differentiate into intermediate mesoderm that form tubules that express kidney proximal tubule markers.