(617) 525-5863 hpkdcc@partners.org

Professor of Pediatrics

Harvard Medical School and Boston Children's Hospital

A major goal of our present research is to understand the mechanism of cyst formation in polycystic kidney disease. My laboratory takes a developmental approach to organ-based disease, examining how aberrant regulation of developmental pathways results in organ-based disease. A major area of interest is in the role of integrins in kidney development and disease. We have found that coordinate signal transduction between a3b1 integrin and the receptor tyrosine kinase c-Met regulates Wnt gene expression during development. We are presently investigating mis-regulation of this pathway in PKD.

PUBLICATIONS

For more publications click here.

Pandey, P., Qin, S., Ho, J. Zhou, J. and Kreidberg, J.A. Systems biology approach to identify transcriptional reprogramming and microRNA targets during progression of Polycystic Kidney Disease. (In Press, BMC System Biology 2011 Apr 25;5:56. PMID: 21518438

Qin, S., Taglienti, M., Nauli, S.M., Contrino, L.,Takakura, A., Zhou, J. and Kreidberg, J.A. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease J. Clinical Investigation 2010 120(10):3617-3628

Hartwig, S., Ho, J., Pandey, P., MacIsaac, K., Taglienti, M., Xiang, M., Alterovitz, G., Ramoni, M., Fraenkel. E., and Kreidberg, J.A. . Genomic Characterization of Wilms’ Tumor Suppressor-1 Targets in Nephron Progenitor Cells during Kidney Development. Development. 2010 137:1189-1203